Issue: 2019 > November > case report

Exceptional response of brain metastases to short course nivolumab while on high-dose steroids

W.K. de Jong, A.C.M. Mulders, W. Westendorp, A. Becker
AbstractFull textPDF


In this manuscript, we describe a patient with an exceptional response of brain metastases from lung cancer to short course nivolumab while on high-dose steroids. This case shows that immunotherapy can cause delayed and enduring responses even in patients with poor predictive parameters for treatment success, such as low programmed death ligand-1 (PDL1) expression and long-term treatment with high-dose corticosteroids. Secondly, it underscores the importance of follow up after the administration of immunotherapy, even in cases with a deemed poor prognosis and few received cycles of immunotherapy.