Issue: 2019 > June > case report

Cardiac arrest following chloroquine overdose treated with bicarbonate and lipid emulsion

C. Bethlehem, M. Jongsma, J. Korporaal-Heijman, J.P. Yska
AbstractFull textPDF


We describe a 27-year-old female with repeated episodes of pulseless electrical activity due to intoxication with a substance that was unidentified at presentation. Severe QRS widening was observed and empiric treatment with sodium bicarbonate and intravenous lipid emulsion was administered.
In this case, intraosseous administration of lipid emulsion failed to improve haemodynamic parameters, suggesting that this dose remained in the bone marrow compartment. We recommend that physicians become aware of this possibility and to avoid intraosseous administration of lipid emulsion.