Issue: 2015 > August > case report

Clozapine intoxication due to cessation of smoking and infection

E.M. ten Bokum, H.L.A. van de Oever, D.W.S. Radstake, M.E.L. Arbouw
AbstractFull textPDF


We report on a patient on clozapine treatment who was admitted to our hospital with pneumonia. He had stopped smoking a few weeks before admission. The serum clozapine rose to a toxic level, most likely due to the combination of infection and smoking cessation. Physicians and pharmacists are often not aware of risk factors for decreased metabolism of clozapine.