Issue: 2009 > September > special report

The Dutch EPS Registry: Increasing the knowledge of encapsulating peritoneal sclerosis

M.R. Korte, E.W. Boeschoten, M.G.H. Betjes, on behalf of the EPS registry


Encapsulating peritoneal sclerosis (EPS) is a rare
condition characterised by fibrotic thickening of the
visceral peritoneum, leading to encapsulating of the
intestines with partial or total intestinal obstruction.
EPS is a serious complication of peritoneal dialysis (PD)
with high morbidity and a mortality exceeding 50%. At
present, there is uncertainty concerning the incidence
and the risk factors involved in the development of EPS .
To address these questions a nationwide registry has been initiated. The primary goals of the registry are to record the incidence of EPS and investigate the association of different variables, such as PD duration, medication, dialysis solutions and kidney transplantation with EPS. The registry will improve the knowledge of EPS and will serve to develop guidelines and necessary management strategies. From the registry different research activities can be initiated. A major challenge lies in the establishment of criteria that allow a timely diagnosis of EPS. At present, there are no diagnostic tools that can accurately detect EPS at an early stage. For this reason, besides patients with proven EPS, the clinical suspicion of EPS will be a sufficient criterion for inclusion in the registry. This nationwide EPS registry is currently enrolling patients.