In this report we present two patients with intracranial
multiple midline tumours in the suprasellar region and
pineal gland. We postulate that in a patient with multiple
midline tumours and normal values of the tumour markers human chorionic gonadotropin and α-fetoprotein in serum and cerebrospinal fluid, the only possible diagnosis is a germinoma. In such a situation no histological confirmation is required to start low-dose radiotherapy.