Issue: 2007 > November > original article

Intracranial multiple midline germinomas: is histological verification crucial for therapy?

P. van Battum, M.S.P. Huijberts, A.C. Heijckmann, J.T. Wilmink, A.C. Nieuwenhuijzen Kruseman


In this report we present two patients with intracranial
multiple midline tumours in the suprasellar region and
pineal gland. We postulate that in a patient with multiple
midline tumours and normal values of the tumour markers human chorionic gonadotropin and α-fetoprotein in serum and cerebrospinal fluid, the only possible diagnosis is a germinoma. In such a situation no histological confirmation is required to start low-dose radiotherapy.