Issue: 2003 > December > case report

Successful treatment of metastatic esthesioneuroblastoma

F.Y.F.L. de Vos, P.H.B. Willemse, E.G.E. de Vries


This case report describes a patient with a metastasised
olfactorial esthesioneuroblastoma Hyams grade 4 who
has been treated with debulking surgery and radiotherapy.
After relapse in lymph node, lung and brain, he received
additional irradiation and six cycles of carboplatin, vincristine and cyclophosphamide intravenously every three weeks.
The patient has now been disease free for 7.8 years. Our
data suggest that metastatic esthesioneuroblastoma is
sensitive to platinum-based chemotherapy. This patient
illustrates that this tumour is very sensitive to platinumbased chemotherapy and that durable complete response can be achieved, even in a metastatic ENB.