Issue: 2003 > October > case report

Unexpected survival from severe metformin-associated lactic acidosis

P.J.C.M. Schure, A. de Gooijer, A.R.H. van Zanten


Lactic acidosis is a recognised complication of the antihyperglycaemic biguanide agent metformin, especially in patients with renal failure. We report a case of severe lactic acidosis and hypothermia due to metformin treatment and renal impairment. The favourable outcome despite extremely unfavourable clinical signs and symptoms for survival after admission and initial treatment was unexpected. Specific aspects of the clinical course are addressed.