Issue: 2013 > July/August > review

Immunosuppressive drugs after solid organ transplantation

M.S. van Sandwijk, F.J. Bemelman, I.J.M. ten Berge


In recent years solid organ transplantation has been
rapidly developed as a therapeutic intervention that is
life-saving and greatly contributes to a better quality of
life in organ recipients. The rapid development has been
made possible because of a drastic expansion in the
immunosuppressive repertoire. Unfortunately, the side
effects of these drugs can be severe, which is one of the
reasons that life expectancy of transplant patients still
significantly falls short of that of the general population. In
this review manuscript we will discuss current and future
immunosuppressive strategies that are employed in solid
organ transplantation. Expanding our understanding of the human immune system will hopefully provide us with
newer, smarter drugs that promote immunotolerance
without the side effects observed today.