DNA vaccination is an attractive method for therapeutic
vaccination against intracellular pathogens and cancer.
This review provides an introduction into the DNA
vaccination field and discusses the pre-clinical successes
and most interesting clinical achievements thus far.
Furthermore, general attributes, mechanism of action
and safety of DNA vaccination will be discussed. Since
clinical results with DNA vaccination so far show room
for improvement, possibilities to improve the delivery
and immunogenicity of DNA vaccines are reviewed. In
the coming years, these new developments should show
whether DNA vaccination is able to induce clinically relevant responses in patients.