Issue: 2007 > November > case report

A patient with hyperglycaemia and normal HbA1c due to impaired glycation

M.J.M. Diekman, H.J.M. Salden, J.H. DeVries


A diabetic Caucasian woman presented with discrepantly
low HbA<sub>1c</sub> values compared with her glycaemia. High-performance liquid chromatography (HPLC) analysis disclosed 80% HbA and 20% HbI Philadelphia (16&#945;2 lys &#8594; glut). The calculated glycosylation gap from the fructosamine level was 1.2%. The haemoglobin &#945;/&#946; glycation ratios, as
measured by electron spray ionisation mass spectroscopy (ESI-MS), for the patient and her three children also carrying the mutation were decreased by values of 0.56 and 0.51, 0.50 and 0.49, respectively (reference value 0.66).