Issue: 2006 > July-August > original article

Trends in fungaemia and antifungal susceptibility in the Netherlands

F. Verduyn Lunel, J.G.M. Koeleman, L. Spanjaard, C. Vandenbroucke-Grauls, C. Schultz, H.A. Verbrugh, G. Vos, A. Troelstra, E. Mascini, P.E. Verweij, A. Voss


We retrospectively evaluated fungaemia over the period
1996 to 2001 in five university hospitals. Over 350,000
blood cultures were collected during more than 7 million
days of hospitalisation. The average rate of fungaemia
over the six-year period was 0.82 per 10,000 patient
days (range 0.65 to 1.21 per 10,000 patient days). The
proportion of bloodstream infections caused by <i>Candida albicans</i> remained stable throughout the study period with a mean of 53% (range 48 to 62%). This is a change from trends described in previous studies, including a survey performed in the Netherlands. This study shows a new, stable rate of fungaemia and no further signs of increasing rate of infections due to non-<i>albicans Candida</i> species.
Susceptibility to all tested antifungal agents remained
stable throughout the study period.