Issue: 2006 > April > case report

Successful treatment of liposomal amphotericin B refractory <i>Candida glabrata</i> fungaemia in a patient undergoing a stem cell transplantation

B.A.J. Veldman, P.E. Verweij, N.M.A. Blijlevens


Blood stream infections caused by <i>Candida glabrata</i> are difficult to manage. We describe a patient who underwent an allogeneic peripheral stem cell transplantation for acute myeloid leukaemia. The patient developed <i>C. glabrata</i> fungaemia that was refractory to liposomal amphotericin B therapy. After changing the therapy to caspofungin, blood cultures became sterile within two days and the
patient recovered clinically. The patient died shortly after
due to graft-versus-host disease and at autopsy there was no evidence of residual or persistent <i>Candida</i> infection. Caspofungin was effective in liposomal amphotericin-B refractory <i>C. glabrata</i> fungaemia and proved to rapidly clear the infection. Treatment options for candidaemia are discussed.