Issue: 2013 > June > special report

Chest pain in sickle cell disease

S.H. Tonino, E. Nur, H.M. Otten, J.J. Wykrzykowska, J.B.L. Hoekstra, B.J. Biemond


The differential diagnosis of chest pain in a patient with
sickle cell disease is difficult and may encompass several
serious conditions, including chest syndrome, pulmonary
embolism and infectious complications. In this manuscript
we provide an overview on the various underlying diseases
that may cause chest pain in patients with sickle cell
disease and provide clues for a proper diagnostic workup.