Issue: 2006 > April > case report

Successful treatment of liposomal amphotericin B refractory <i>Candida glabrata</i> fungaemia in a patient undergoing a stem cell transplantation



CASE REPORT
B.A.J. Veldman, P.E. Verweij, N.M.A. Blijlevens
AbstractPDF

Abstract

Blood stream infections caused by Candida glabrata are difficult to manage. We describe a patient who underwent an allogeneic peripheral stem cell transplantation for acute myeloid leukaemia. The patient developed C. glabrata fungaemia that was refractory to liposomal amphotericin B therapy. After changing the therapy to caspofungin, blood cultures became sterile within two days and the
patient recovered clinically. The patient died shortly after
due to graft-versus-host disease and at autopsy there was no evidence of residual or persistent Candida infection. Caspofungin was effective in liposomal amphotericin-B refractory C. glabrata fungaemia and proved to rapidly clear the infection. Treatment options for candidaemia are discussed.