Issue: 2009 > May > case report

Food-dependent Cushings syndrome

C. Messidoro, J.W.F. Elte, M. Castro Cabezas, M. van Agteren, A. Lacroix, W.W. de Herder


It has recently been proposed that other hormones than
ACTH can control cortisol production in Cushings
syndrome with bilateral adrenal hyperplasia. We present
a case of food-dependent Cushings syndrome. After a
positive response of cortisol production during mixed
meals, several tests identified glucose-dependent
insulinotropic polypeptide (GIP) as the driving hormone
responsible for the cortisol overproduction. Identification
of aberrant hormone receptor expression is of importance because it may create a possibility for pharmacological treatment.