AbstractPDF
Abstract
Neuromyopathy is a rare side effect of chronic colchicine
therapy, most often occurring in patients with chronic
renal failure. Drugs interacting with colchicine metabolism through CYP3A4 and P-glycoprotein can
accelerate accumulation and toxicity. We describe a case
of an interaction between clarithromycin and colchicine
resulting in acute neuromyopathy, and we conclude that
combined use of macrolides and colchicine should be
avoided.
